The route from Strasbourg to Lyon traverses a significant part of eastern France, connecting two culturally rich cities with direct TGV trains. The journey typically takes around 4 hours, covering approximately 500 kilometers. Strasbourg, known for its picturesque canals and the stunning Strasbourg Cathedral, presents a charming blend of French and German influences. In contrast, Lyon offers a rich culinary heritage, famous for its gastronomy and historical sites such as the Basilica of Notre-Dame de Fourvière. On this page, you will find vital information for preparing your journey from Strasbourg to Lyon, including train schedules, ticket purchasing options, and frequently asked questions regarding this rail route.