The train route from Berlin to Mannheim connects Germany's capital to a prominent city in the Rhine-Neckar metropolitan region. This journey spans approximately 640 kilometers and typically takes around 4 to 4.5 hours. Passengers can travel on Intercity-Express (ICE) trains, which offer a comfortable and efficient service between these cities. Berlin, known for its rich history and cultural heritage, contrasts with Mannheim, recognized for its rectangular street layout and as a hub of industry and commerce. On this page, you'll find detailed information on train schedules, ticketing options, and frequently asked questions regarding the Berlin to Mannheim rail route.