The railway service between Guimaraes and Santo Tirso is primarily served by regional trains, offering a comfortable and scenic journey through the northern part of Portugal. The Alfa Pendular service operates on this route, with a maximum speed of approximately 120 km/h (75 mph). The journey typically takes around 50 minutes, making it an efficient option for both locals and tourists. Additionally, the Intercity services also connect these two destinations, though they may take slightly longer due to more stations and stops along the way.
Both types of trains feature standard amenities, including seating arrangements designed for easy access and spacious interiors, ensuring a pleasant travel experience. The Alfa Pendular is known for its reliability and frequent schedules, catering well to those traveling between Guimaraes and Santo Tirso.