Connecting Through Mendrisio’s Train Station. Mendrisio’s train station serves as a vital conduit for travelers exploring the scenic landscapes of Switzerland and beyond. As part of the Swiss Federal Railways network, Mendrisio Station offers seamless connections to cities like Lugano and Milan, making it an excellent choice for both local commuters and international travelers. The station features comfortable waiting areas, ticketing services, and helpful information desks, ensuring a smooth journey for every passenger. With convenient schedules and picturesque views surrounding the station, Mendrisio is a wonderful starting point for your Swiss adventure.