The Diyarbakir to Malatya route is primarily served by the state-owned TCDD trains, providing standard rail service options for passengers. The fastest service on this route is the Regional Train, which operates at speeds of up to 120 km/h (75 mph), completing the journey in approximately 4 hours. This train typically makes several stops at key towns along the way, allowing travelers to experience the local scenery. For those looking for a more direct route, the more frequent express services are available, which can reduce travel time slightly but still generally stick within the same range of duration. Onboard amenities include basic seating and occasional food service, aiming to ensure a comfortable journey. While the speed is modest compared to high-speed trains found in other countries, the service provides a reliable connection between these two important cities in southeastern Turkey.