Discover the Charm and Efficiency of the Lyon to Strasbourg Route. Traveling from Lyon to Strasbourg has never been more convenient or enjoyable with France’s robust train network. Covering approximately 500 kilometers, this route connects the vibrant city of Lyon with the picturesque beauty of Strasbourg. The journey usually takes around 3.5 to 4 hours, making it an ideal option for both business trips and leisurely explorations. With frequent departures throughout the day, the Lyon to Strasbourg train schedule is designed to accommodate diverse travel plans, providing a seamless and comfortable travel experience.