The train journey from Düsseldorf to Karlsruhe serves as a vital connection between the North Rhine-Westphalia and Baden-Württemberg regions of Germany. This route typically spans a distance of approximately 350 kilometers, allowing travelers to reach their destination in around 3 to 4 hours, depending on the service chosen. Düsseldorf is well-regarded for its trade fairs and cultural institutions, while Karlsruhe boasts a rich history and beautiful parks. On this page, you’ll find comprehensive details to assist with planning your trip from Düsseldorf to Karlsruhe, including timetables, ticket pricing, and frequently asked questions about this rail line.