The ICE train from Mannheim to Bielefeld departs from Mannheim Hbf at 5:32 AM, with the last train leaving at 8:45 PM. Key stops on this route include Frankfurt, Dortmund, and Gütersloh. The journey takes approximately 3.5 hours, with the ICE providing high-speed travel throughout. Tickets are priced from €33 (approximately $44 USD) for second class, with first class options available for added comfort. Customers can reserve a seat easily and check the full timetable and schedule online, ensuring they find the best price for their trip.